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. Author manuscript; available in PMC: 2018 Jun 28.
Published in final edited form as: J Am Chem Soc. 2017 Nov 2;139(45):16365–16376. doi: 10.1021/jacs.7b09527

Scheme 2.

Scheme 2

Competing H2S release pathways for O-alkyl thiocarbamates with electron withdrawing groups. (a) H2O2-mediated COS/H2S release and (b) base-mediated isothiocyanate formation followed by hydrolysis to generate H2S.