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. Author manuscript; available in PMC: 2019 Mar 1.
Published in final edited form as: Mol Cell. 2018 Mar 1;69(5):757–772.e7. doi: 10.1016/j.molcel.2018.01.037

Figure 6. GPS2 retrograde translocation supports mitochondrial biogenesis during 3T3-L1 adipogenesis.

Figure 6

(A) GPS2 binding to mitochondrial genes increases upon differentiation (GSE57779).

(B) Relative expression of adipo-specific neMITO genes by RT-qPCR.

(C) Mitochondrial biogenesis, as measured by increase in mtDNA content, is impaired in GPS2-KD cells.

(D) WB of fractionated extracts showing mitochondria-to-nucleus translocation of GPS2 after 3h of differentiation.

(E)(F) GPS2 desumoylation and translocation (E) and mitochondrial biogenesis (F) during adipogenesis are impaired in cells transfected with siSENP1 (siS1).

* indicate p-value<0.05; ** indicate p-value<0.01.