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. Author manuscript; available in PMC: 2019 Jun 1.
Published in final edited form as: Biometrics. 2017 Oct 31;74(2):714–724. doi: 10.1111/biom.12790

Table 1.

The unnormalized joint posterior distribution of the parameters given the data, xi and yi. Following work by Horton et al. (2017), we incorporate population level parameters for pulse mass, width, baseline and half-life as we are jointly modeling a population of subjects. xi and yi are the vector of hormone concentration values for subject i.

Model component Hierarchical Specification
(a) Likelihood
i=1mL(xi,yiθs,ix,θb,ix,θh,ix,θs,iy,θb,iy,θh,iy,e,i)×
(b) Joint prior pulse locations
i=1mπ(τiyτix,ρ,ν)π(τixβ,R,γ)π(ρ)π(ν)×
(c) Joint prior pulse Mass & width
i=1m{k=1Ns,ixπ((αs,ikx,ωs,ikx)Ns,ix,μs,ix,ϒsx)l=1Ns,iyπ((αs,ily,ωs,ily)Ns,iy,μs,iy,ϒsy)}×
i=1mπ((μs,ix,μs,iy)μsx,y,sx,y)π(μsx,y)π(sx,y)π(ϒsx)π(ϒsy)×
(d) Priors baseline
i=1mπ(θb,ixμbx,σx,b2)π(μbx)π(σx,b2)i=1Nπ(θb,iyμby,σy,b2)π(μby)π(σy,b2)×
(e) Priors half-life
i=1mπ(θh,ixμhx,σx,h2)π(μhx)π(σx,h2)i=1Nπ(θh,iyμhy,σy,h2)π(μhy)π(σy,h2)×
(f) Priors model error
i=1mπ(e.i)