Table 3.

Table of the parameters combinations used for the simulation scenarios. The parameters listed are on the population level unless otherwise specified.

			Scenario
			1	2	3	4	5	6	7
Parameter	Units (all)	Trigger (x)	Response (y)
Pulse mass
Pop. mean (μα)	ng/ml	3	3	1	3	3	1	1
Pop. std. (σα)	ng/ml	0.5	0.5	0.5	0.5	0.5	0.5
Subj. std. (να)	ng/ml	0.5	0.5	0.5	0.5	0.5	0.5
Correlation ( ${\mu }_{\alpha ,i}^x\&{\mu }_{\alpha ,i}^y$)		0.8	0.8	0.8	0.8	0.8	0.8	0.8
Pulse width
Pop. mean (μω)	min.2	25	25	25	25	25	25	25
Pop. std. (σω)	min.2	2	2	2	2	2	2	2
Subj. std. (νω)	min.2	0.5	0.5	0.5	0.5	0.5	0.5	0.5
Baseline
Pop. mean (μb)	ng/ml	4	4	4	4	4	4	4	4
Pop. std.( σb)	ng/ml	0.4	0.4	0.4	0.4	0.4	0.4	0.4	0.4
Half-life
Pop. mean (μh)	min.	45	45	200	45	45	200	200
Pop. std. (σh)	min.	2	2	2	2	2	2	2
Model error (log-scale)
${\sigma }_{\epsilon }^2$	log conc.2	0.005	0.005	0.005	0.005	0.005	0.005	0.005	0.005
Trigger pulse strauss model
Rate(β)		4
Repulsion Level 1 (γ1)		0
Repulsion Level 2 (γ2)		0.1
Repulsion dist. Level 1 (R1)	min.	36
Repulsion dist. Level 2 (R2)	min.	96
Response pulse model
Cox model
Cluster size (ρ)	#		0.7	1			0.7	0.7
Cluster width (υ)	min.		10	10			10	10
2nd Trigger Pulse rate	per hr						0.10	0.30
Strauss model
Rate(β)						4
Repulsion Level 1 (γ1)						0
Repulsion Level 2 (γ2)						0.1
Repulsion dist. Level 1 (R1)	min.					36
Repulsion dist. Level 2 (R2)	min.					96