Figure 1.

Domain structure of CFI. Variants identified in our AMD cohort are positioned along the domains of CFI. Those above the domains were present in cases and controls, whereas those beneath the domains were exclusively in cases (red lines, hypoactive alleles; blue lines, benign; green line, hyperactive; black line, not tested). Complement factor I has a FI membrane-attack-complex domain (FIMAC), a CD5-like/scavenger receptor cysteine-rich (SRCR) domain, two low-density lipoprotein receptor (LDLR) domains, and a serine protease domain.