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. 2018 Jun;13(6):1019–1025. doi: 10.4103/1673-5374.233445

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Copyright: © Neural Regeneration Research

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Changes in the density of dendritic spines and synaptic buttons in Purkinje cells during synaptic aging.

(A) Fitted curve between spine density (Y) and age (X): The regression equation is shown with the formula: Y = 0.025X³ − 0.416X² + 2.172X − 1.586 (R² = 0.989, P < 0.05). The dendritic spines at P12M and P18M were compared with control (P3M). (B) Fitted curve between synaptic buttons (Y) and age (X): The regression equation is shown with the formula: Y = 0.013X³ − 0.244X² + 1.384X − 0.973 (R² = 0.972, P < 0.05). Synaptophysin-immunoreactive puncta at P12M and P18M were compared with control (P3M). *P < 0.05, vs. control (n = 60; one-way analysis of variance followed by Student-Newman-Keuls analysis). P3, P14: Postnatal 3, 14 days; P1M, P3M, P6M, P12M, P18M: postnatal 1, 3, 6, 12 and 18 months.