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. 2018 Jun;13(6):1019–1025. doi: 10.4103/1673-5374.233445

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Copyright: © Neural Regeneration Research

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Synaptic ultrastructure during synaptic development and aging (transmission electron microscope).

(A) At P14, synapses had a presynaptic membrane, synaptic cleft and postsynaptic membrane. There were numerous synaptic vesicles in the presynaptic terminal, and obvious thick pre- and post-synaptic membranes. (B) At P30, synapses looked more mature with typical synaptic structure. (C, D) At P18M, the aged synapse had fewer synaptic vesicles and thin pre- and post-synaptic membranes. Arrows: Synapse; arrowheads: synaptic vesicles. Scale bar: 300 nm. P14, P30: Postnatal 14, 30 days; P18M: Postnatal 18 months.