Table 3.
Univariate and multivariate analyses of prognostic factors associated with cancer-specific survival
| Univariate analysis | Multivariate analysis | |
|---|---|---|
| HR (95% CI) P-value | HR (95% CI) P-value | |
| Age (years) | 0.024 | 0.421 |
| < 60 | 1.00 | 1.00 |
| ≥ 60 | 1.292 (1.035, 1.613) | 1.130 (0.839, 1.522) |
| Sex | 0.252 | |
| Female | 1.00 | |
| Male | 0.875 (0.695, 1.100) | |
| Tumor size (cm) | < 0.001 | 0.997 |
| < 5 | 1.00 | 1.00 |
| ≥ 5 | 1.505 (1.204, 1.880) | 0.999 (0.737, 1.356) |
| Tumor location | < 0.001 | 0.027 |
| Lower third | 1.00 | 1.00 |
| Upper/Middle third | 1.524 (1.209, 1.922) | 1.453 (1.044, 2.022) |
| Histological grade | 0.340 | |
| Well differentiated | 1.00 | |
| Poorly differentiated | 1.179 (0.840, 1.655) | |
| Lauren histotype | 0.235 | |
| Intestinal | 1.00 | |
| Diffuse / Mixed | 0.859 (0.669, 1.104) | |
| LVI | < 0.001 | 0.041 |
| Absent | 1.00 | 1.00 |
| Present | 1.602 (1.299, 1.977) | 1.294 (1.011, 1.657) |
| pT stage | 0. 001 | |
| pT1/2 | 1.00 | |
| pT3/4 | 2.960 (1.573, 5.571) | |
| pN stage | < 0.001 | |
| pN0/1 | 1.00 | |
| pN2/3 | 3.743 (2.734, 5.124) | |
| Dissected lymph nodes | 0.118 | |
| ≤ 29 | 1.00 | |
| > 29 | 1.107 (0.974, 1.258) | |
| TNM stage | < 0.001 | < 0.001 |
| II | 1.00 | 1.00 |
| III | 4.597 (3.218, 6.567) | 4.625 (2.883, 7.421) |
| Operation type | 0.015 | 0.669 |
| Subtotal | 1.00 | 1.00 |
| Total/extended | 1.340 (1.058, 1.697) | 1.083 (0.752, 1.558) |
| Complications | 0.755 | |
| No | 1.00 | |
| Yes | 0.953 (0.701, 1.293) | |
| Performance status | 0.548 | |
| 0 | 1.00 | |
| 1/2 | 0.924 (0.716, 1.194) | |
| BMI (Kg/m2) | 0.159 | |
| < 18.5 | 1.00 | |
| 18.5≤ | 1.173 (0.940, 1.464) | |
| PNI | < 0.001 | 0.085 |
| ≥ 45 | 1.00 | 1.00 |
| < 45 | 1.777 (1.313, 2.404) | 1.505 (0.945, 2.396) |
| Anemia | 0.231 | |
| No | 1.00 | |
| Yes | 1.155 (0.912, 1.463) | |
| CONUT | < 0.001 | 0.017 |
| ≤ 2 | 1.00 | 1.00 |
| ≥ 3 | 1.576 (1.255, 1.978) | 1.553 (1.080, 2.232) |
| CEA | 0.009 | 0.269 |
| Normal | 1.00 | 1.00 |
| Elevated | 1.407 (1.087, 1.822) | 1.222 (0.857, 1.742) |
| CA19–9 | 0.002 | 0.033 |
| Normal | 1.00 | 1.00 |
| Elevated | 1.555 (1.183, 2.042) | 1.427 (1.029, 1.979) |
| CA72–4 | 0.012 | 0.476 |
| Normal | 1.00 | 1.00 |
| Elevated | 1.447 (1.086, 1.927) | 1.125 (0.814, 1.555) |
Abbreviations: LVI lymphatic vessel infiltration, TNM tumor-node-metastasis staging, BMI body mass index, PNI prognostic nutritional index, CONUT controlling nutritional status, CEA carcinoembryonic antigen, CA carbohydrate antigen