Table 4.
meQTL p value thresholdb | ||||
---|---|---|---|---|
Permissivec | Intermediated | Stringente | ||
ASD EWAS p valuea | 1 × 10−3 | 1.20 (0.041) | 1.11 (0.218) | 1.11 (0.243) |
1 × 10−4 | 1.46 (0.134) | 1.71 (0.089) | 1.50 (0.205) |
Enrichment fold statistics and p values based on 1000 permutations are reported
aASD to DNAm association p value defined from meta-analysis
bSNP to CpG association p value thresholds
cp values in each methylation processing batch that allowed for 100% power to detect a 5% methylation difference with each addition of minor allele (see “Methods”)
dp values in each methylation processing batch that allowed for 90% power to detect same methylation difference
ep values in each methylation processing batch that allowed for 80% power to detect same methylation difference