Fig. 2.

Overall change from baseline in patient-reported EORTC QLQ-C30 global health status/QoL scores in patients with a baseline ECOG PS of 0 (a) or 1 (b). C Cycle, D Day, ECOG PS Eastern Cooperative Oncology Group performance status, EORTC QLQ-C30 European Organisation for Research and Treatment of Cancer core quality-of-life cancer questionnaire, EOT end of treatment, HRQoL health-related quality of life, LSM least square mean, QoL quality of life, SEM standard error of the mean. Changes from baseline in patient-reported EORTC QLQ-C30 global health status/QoL scores were determined using a linear mixed-effect model. Positive changes from baseline indicate improvement in HRQoL. A > 5-point improvement from baseline in HRQoL score was defined as clinically meaningful. Data cut-off: January 4, 2017