Fig. 5.

Change from baseline in EORTC QLQ-C30 pain scores in patients with a best overall response of CR or PR. C Cycle, CR complete response, D Day, EORTC QLQ-C30 European Organisation for Research and Treatment of Cancer core quality-of-life questionnaire, EOT end of treatment, LSM least squares mean, PR partial response, SEM standard error of the mean. Changes from baseline in patient-reported EORTC QLQ-C30 pain scores were determined using a linear mixed-effect model. Negative changes from baseline indicate a reduction in pain. A > 5-point change from baseline in pain score was defined as clinically meaningful. Data cut-off: January 2, 2017