Fig. 6.

Exploratory AUC analysis for the mean difference in change from baseline in EORTC QLQ-C30 pain scores between treatment arms. AUC area-under-the-curve, CI confidence interval, EORTC QLQ-C30 European Organisation for Research and Treatment of Cancer core quality-of-life questionnaire. AUC analysis for change from baseline in mean EORTC QLQ-C30 pain scores was performed for the indicated subgroups in each treatment arm. Larger negative values indicate a greater reduction in pain. ^aCompared between treatment arms using a paired t-test. ^bp-values reported are nominal. No multiplicity adjustments were made, and therefore, statistical interpretation should be made with caution. ^cMeasurable disease data were based on a data cut-off date of January 2, 2017. All other subgroup data were based on a data cut-off date of January 4, 2017