Table 5.

Coefficient of determination (R²) of COSSMO models and MaxEntScan

	All events		Alternatively spliced
Model	Acceptor n = 172 940	Donor n = 175 000	Acceptor n = 22 564	Donor n = 25 865
MaxEntScan	0.080	0.195	−0.105	0.038
Independent	0.389 (±0.003)	0.438 (±0.005)	0.187 (±0.003)	0.208 (±0.009)
Comm-net	0.421 (±0.007)	0.552 (±0.001)	0.229 (±0.003)	0.372 (±0.008)
LSTM	0.614 (±0.005)	0.628 (±0.003)	0.430 (±0.006)	0.453 (±0.005)
Resnet + LSTM	0.612 (±0.006)	0.618 (±0.004)	0.420 (±0.007)	0.448 (±0.004)

Note: The coefficient of determination is computed using the class prior $1/K$ (uniform distribution over alternative splice sites) as baseline. For COSSMO, R² is computed as the average of five cross-validation folds with standard errors given in parentheses. The right columns show loss only for those events that contain two or more annotated splice sites.