Fig. 3.

The clustering-based method identifies clones with high confidence on simulated data. The spectral (circles) and hierarchical (diamonds) clustering-based methods were applied to identify clonally related sequences in 40 simulated datasets (10 datasets from each of 4 simulated individuals R1–R4) generated by Gupta et al. (Gupta et al., 2017). Performance was assessed by calculating (A) sensitivity and (B) specificity on three junction-length domains. Mean performance is indicated by the solid bars (spectral) and dashed bars (hierarchical)