Fig. 7.

The spectral clustering-based method identifies clones with more shared mutations in subjects with acute dengue virus infections. The spectral and hierarchical clustering-based methods were applied to peripheral blood B cell repertoires from 58 subjects with acute dengue virus infections (Parameswaran et al., 2013). The total number of shared mutations in the V segment (up to the start of the junction) was determined for clones that were among the 50 largest inferred by both the spectral clustering and hierarchical clustering methods (covering $\sim 25\%$ of the total reads), and the difference between the methods was calculated. Each number represents a single clone, with the number specifying the individual where the clone was observed and the x-axis label indicating the V gene used by the clone