Fig. 8.

Compactness and isolation properties vary across repertoire datasets. For each dataset, the maximum-distance-within clones (compactness, black) and minimum-distance-between clones (isolation, grey) were calculated across all clones. Results are shown for simulated datasets from Ralph and Matsen (Ralph and Matsen, 2016) (A) sim-50-1.0-mut, (B) sim-100-1.0-mut, (C) sim-200-1.0-mut, and Gupta et al. (Gupta et al., 2017) (D) R1.1. The horizontal dashed line indicates the threshold of 0.15 normalized Hamming distance used by the hierarchical clustering-based method