Table 2.
Distribution of the top-10 most frequent super-families and families with known ligand interactions
| Super-family | No. of prots. | Family | No. of prots. | |
|---|---|---|---|---|
| 1 | Protein kinase-like (d.144.1) | 47 | Protein kinases, catalytic subunit (d.144.1.7) | 39 |
| 2 | P-loop containing nucleoside triphosphate hydrolases (c.37.1) | 43 | Fibronectin type III (b.1.2.1) | 28 |
| 3 | Immunoglobulin (b.1.1) | 41 | Eukaryotic proteases (b.47.1.2) | 25 |
| 4 | NAD(P)-binding Rossmann-fold domain (c.2.1) | 32 | EGF-type module (g.3.11.1) | 24 |
| 5 | Trypsin-like serine proteases (b.47.1) | 31 | Immunoglobulin I set (b.1.1.4) | 23 |
| 6 | Fibronectin type III (b.1.2) | 28 | SH2 domain (d.93.1.1) | 22 |
| 7 | EGF/Laminin (g.3.11) | 27 | Nuclear receptor ligand-binding domain (a.123.1.1) | 18 |
| 8 | SH2 domain (d.93.1) | 22 | Cyclin (a.74.1.1) | 15 |
| 9 | Cysteine proteinases (d.3.1) | 20 | Pleckstrin-homology domain (b.55.1.1) | 15 |
| 10 | Nuclear receptor ligand-binding domain (a.123.1) | 19 | Tyrosine-dependent oxidoreductases (c.2.1.2) | 15 |