Table 2.
Gene-ontology terms upregulated in adult GBM tumor-associated macrophages compared to DIPG tumor-associated macrophages
| GO Terms upregulated in aGBM TAMs vs. DIPG TAMs | ||
|---|---|---|
| GO Term | p-value | Genes |
| Inflammatory response | 4.70E-13 | NFKBIZ, IL6, CCL3, OLR1, PTGS2, CXCL2, CXCL8, NFKB1, NLRP3, CCL5, CCL4, CCRL2, FOS, IL1B, NAIP, CLEC7A, NFE2L2, TNFAIP3, IL1A |
| Positive regulation of smooth muscle cell proliferation | 5.66E-07 | NAMPT, IL6, EREG, PTGS2, HBEGF, NR4A3, CCL5 |
| Cellular response to interleukin-1 | 1.55E-06 | ICAM1, IL6, CCL3, CXCL8, NFKB1, CCL5, CCL4 |
| Positive regulation of transcription from RNA polymerase II promoter | 1.57E-06 | EGR1, NAMPT, IL6, EGR2, CCNH, NR4A2, CCNL1, NFKBIA, NFKB1, FOSB, NR4A3, NLRP3, FOS, ATF3, RGCC, IL1B, NFE2L2, IL1A, KLF4 |
| Immune response | 8.70E-06 | GPR183, IL6, CCL3, CXCL2, IL1RN, CXCL8, IL1B, CCL5, SLED1, CCL4, GBP2, IL1A |
| Cellular response to tumor necrosis factor | 1.98E-05 | ICAM1, IL6, CCL3, CXCL8, NFE2L2, CCL5, CCL4 |
| Chemokine-mediated signaling pathway | 2.96E-05 | CCRL2, CCL3, CXCL2, CXCL8, CCL5, CCL4 |
| Positive regulation of gene expression | 5.38E-05 | IL6, LIMS1, CCL3, RGCC, MDM2, IL1B, NFE2L2, KLF4, IL1A |