Table 1.

Screening data for control 1 and basic acyclic amides 2–37.

Ar	Cmpd	R1 & R2	CC50 (μM)
			HT29	PC3	MDA-MB-231
	1	R1 = H, R2 = -CH2CH2N(CH3)2	0.65±0.03	3.12±0.15	2.67±0.08
	2	R1 = H, R2 = -CH2CH2CH2N(CH3)2	2.46±0.14	6.99±0.19	5.18±0.46
	3	R1 = H, R2 = -CH2CH2N(CH2CH3)2	1.54±0.05	5.45±0.35	4.20±0.17
	4	R1 = H, R2 = -CH2CH2CH2N(CH2CH3)2	1.53±3.33	4.33±0.22	3.19±0.08
	5	R1 = CH3, R2 = -CH2CH2N(CH3)2	1.83±0.04	5.63±0.26	3.98±0.45
	6	R1 = CH3, R2 = -CH2CH2CH2N(CH3)2	2.18±0.03	6.98±0.27	5.41±0.42
	7	R1 = CH2CH3, R2 = -CH2CH2N(CH2CH3)2	1.83±0.04	6.21±0.44	5.22±0.20
	8	R1 = CH3, R2 = -CH2CH2N(CH2CH3)2	1.49±0.02	5.65±0.26	3.77±0.35
	9	R1 = CH2CH3, R2 = -CH2CH2N(CH3)2	1.36±0.05	5.07±0.31	3.96±1.46
	10	R1 = CH3, R2 = -CH2CH2N(CH3)H	2.80±0.07	6.75±0.24	5.84±0.35
	11	R1 = CH3, R2 = -CH2CH2CH2N(CH3)H	2.90±0.05	7.65±0.29	7.66±0.49
	12	R1 = CH2CH3, R2 = -CH2CH2N(CH2CH3)H	2.54±0.10	6.56±0.43	6.65±0.22
	13	R1 = CH2CH3, R2 = -CH2CH2CH2N(CH2CH3)H	1.38±0.05	3.92±0.29	3.03±0.19
	14	R1 = CH(CH3)2, R2 = -CH2CH2CH2N(CH(CH3)2)H	2.30±0.07	4.90±0.23	3.92±0.39
	15	R1 = H, R2 = -CH2CH2CH2N(CH3)2	33.27±2.92	>50.00	>50.00
	16	R1 = H, R2 = -CH2CH2N(CH2CH3)2	19.78±0.77	>50.00	>50.00
	17	R1 = H, R2 = -CH2CH2CH2N(CH2CH3)2	27.12±2.0	>50.00	>50.00
	18	R1 = CH3, R2 = -CH2CH2CH2N(CH3)2	38.92±7.98	>50.00	>50.00
	19	R1 = CH2CH3, R2 = -CH2CH2N(CH2CH3)2	18.40±0.78	>50.00	>50.00
	20	R1 = CH3, R2 = -CH2CH2N(CH2CH3)2	23.97±1.51	>50.00	>50.00
	21	R1 = CH2CH3, R2 = -CH2CH2N(CH3)2	18.15±0.94	>50.00	>50.00
	22	R1 = CH3, R2 = -CH2CH2N(CH3)H	34.53±2.45	>50.00	>50.00
	23	R1 = CH3, R2 = -CH2CH2CH2N(CH3)H	>50.00	>50.00	>50.00
	24	R1 = CH2CH3, R2 = -CH2CH2N(CH2CH3)H	18.18±1.40	>50.00	>50.00
	25	R1 = CH2CH3, R2 = -CH2CH2CH2N(CH2CH3)H	17.48±1.14	>50.00	>50.00
	26	R1 = CH(CH3)2, R2 = -CH2CH2CH2N(CH(CH3)2)H	16.28±0.97	48.28±8.05	>50.00
	27	R1 = H, R2 = -CH2CH2N(CH3)2	6.22±0.44	18.27±1.34	15.05±0.88
	28	R1 = H, R2 = -CH2CH2CH2N(CH3)2	6.08±0.30	13.03±0.74	10.79±0.45
	29	R1 = H, R2 = -CH2CH2N(CH2CH3)2	5.42±0.38	13.88±0.78	12.26±0.34
	30	R1 = CH3, R2 = -CH2CH2N(CH3)2	4.68±0.23	11.44±0.52	10.78±0.65
	31	R1 = CH3, R2 = -CH2CH2N(CH3)H	8.05±0.31	23.06±1.31	16.96±1.04
	32	R1 = H, R2 = -CH2CH2N(CH3)2	1.57±0.07	4.88±0.53	3.63±0.27
	33	R1 = H, R2 = -CH2CH2CH2N(CH3)2	1.05±0.05	3.25±0.13	1.93±0.13
	34	R1 = H, R2 = -CH2CH2N(CH2CH3)2	1.12±0.05	4.48±0.32	3.54±0.24
	35	R1 = CH3, R2 = -CH2CH2N(CH3)2	2.02±0.06	5.88±0.32	3.80±0.51
	36	R1 = H, R2 = -CH2CH2N(CH3)2	6.89±0.58	28.90±2.05	18.06±1.07
	37	R1 = H, R2 = -CH2CH2N(CH3)2	12.67±0.73	>50.00	37.46±3.45