Table 2.

Screening data for basic cyclic amides 38–66.

Ar	Cmpd	R1 & R2	CC50 (μM)
			HT29	PC3	MDA-MB-231
	38		1.81±0.06	5.27±0.32	3.78±0.26
	39		1.65±0.14	5.36±0.18	5.42±0.24
	40		2.98±18.68	6.66±0.43	7.66±0.52
	41		1.41±0.04	4.33±0.23	3.75±0.23
	42		1.16±0.08	4.64±0.23	3.72±0.23
	43		1.55±0.06	5.10±0.36	4.16±0.29
	44	R1, R2 = -(-CH2CH2-)2NCH2CH2CH2N(CH3)2	1.69±0.08	4.28±0.16	3.77±1.18
	45	R1, R2 = -(-CH2CH2-)2NCH2CH2N(CH3)2	2.17±0.06	6.23±0.37	4.05±0.23
	46	R1, R2 = -(-CH2CH2-)2N(pyridin-4-yl)	1.13±0.07	2.76±0.19	3.08±0.07
	47	R1, R2 = -(-CH2CH2-)2CH(pipyridin-1-yl)	1.06±0.05	4.06±0.27	2.61±0.09
	48		1.64±0.07	4.45±0.16	4.10±0.19
	49		4.29±0.19	13.42±0.49	11.50±0.53
	50		2.94±0.16	7.35±0.32	7.21±0.22
	51		2.47±0.67	6.50±0.84	3.69±0.17
	52	R1, R2 = -(-CH2CH2-)2NCH2CH2CH2N(CH3)2	23.75±1.48	>50.00	46.18±2.63
	53	R1, R2 = -(-CH2CH2-)2N(Pyridin-4-yl)	9.20±0.39	21.93±2.16	22.74±2.29
	54	R1, R2 = -(-CH2CH2-)2CH(pipyridin-1-yl)	>50.00	>50.00	>50.00
	55		19.03±1.26	>50.00	>50.00
	56		20.16±1.06	>50.00	>50.00
	57		13.39±0.71	46.49±5.98	41.09±3.78
	58		4.18±0.19	9.62±0.66	10.38±0.59
	59	R1, R2 = -(-CH2CH2-)2N(Pyridin-4-yl)	2.79±0.13	5.45±0.68	6.50±0.77
	60		4.22±0.15	12.28±0.72	11.14±0.56
	61		1.21±0.04	4.94±0.28	3.56±0.28
	62	R1, R2 = -(-CH2CH2-)2NCH2CH2CH2N(CH3)2	1.62±0.06	4.21±0.23	2.90±0.07
	63	R1, R2 = -(-CH2CH2-)2N(Pyridin-4-yl)	5.25±0.20	12.28±0.37	7.71±1.5
	64		1.66±0.04	7.72±0.45	5.58±0.33
	65		1.58±0.04	4.25±0.15	3.61±0.23
	66		2.68±0.12	10.19±0.41	7.19±0.31