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. 2018 May 25;1(2):e1014. doi: 10.1002/jsp2.1014

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© 2018 The Authors. JOR Spine published by Wiley Periodicals, Inc. on behalf of Orthopaedic Research Society

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Pain, structural parameters, and intradiscal pro‐inflammatory cytokines correlate. A, Normalized paw withdrawal threshold vs intervertebral disc (IVD) degeneration. B, Normalized paw withdrawal threshold vs intradiscal tumor necrosis factor‐alpha (TNFα) immunopositivity. C, Normalized paw withdrawal threshold vs intradiscal interleukin (IL)‐1β immunopositivity. D, IVD degeneration vs intradiscal TNFα immunopositivity. E, IVD degeneration vs intradiscal IL‐1β immunopositivity. F, Intradiscal TNFα immunopositivity vs intradiscal IL‐1β immunopositivity