Table 1.
Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis of the KIF26B gene and the interactive, co-localized, and co-expressed genes in breast cancer.
| GO ID | GO term | Term P value | % associated genes | Nr. genes | Associated genes found |
|---|---|---|---|---|---|
| GO: 0004512 | ECM-receptor interaction | 1.5E-9 | 13.41 | 11.00 | [COL1A1, COL1A2, COL4A1, COL6A2, COL6A3, HSPG2, ITGA11, ITGA5, LAMB1, THBS1, THBS2] |
| GO: 0004974 | Protein digestion and absorption | 57.0E-9 | 11.11 | 10.00 | [COL11A1, COL1A1, COL1A2, COL3A1, COL4A1, COL5A1, COL5A2, COL6A2, COL6A3, ELN] |
| GO: 0004510 | Focal adhesion | 310.0E-9 | 6.53 | 13.00 | [COL1A1, COL1A2, COL4A1, COL6A2, COL6A3, IGF1, ITGA11, ITGA5, LAMB1, PDGFRA, PDGFRB, THBS1, THBS2] |
| GO: 0004151 | PI3K-Akt signaling pathway | 1.1E-6 | 4.68 | 16.00 | [COL1A1, COL1A2, COL4A1, COL6A2, COL6A3, CREB3L1, FGF7, GNG2, IGF1, ITGA11, ITGA5, LAMB1, PDGFRA, PDGFRB, THBS1, THBS2] |
| GO: 0004933 | AGE-RAGE signaling pathway in diabetic complications | 120.0E-6 | 7.07 | 7.00 | [COL1A1, COL1A2, COL3A1, COL4A1, MMP2, SERPINE1, TGFB3] |
| GO: 0004390 | Hippo signaling pathway | 340.0E-6 | 5.19 | 8.00 | [DLG1, FRMD6, FZD1, GDF6, LATS2, SERPINE1, SNAI2, TGFB3] |
| GO: 0004270 | Vascular smooth muscle contraction | 420.0E-6 | 5.79 | 7.00 | [ACTA2, ACTG2, CALD1, EDNRA, MRVI1, PRKG1, PTGIR] |
| GO: 0005205 | Proteoglycans in cancer | 460.0E-6 | 4.43 | 9.00 | [CAMK2A, FZD1, HSPG2, IGF1, ITGA5, LUM, MMP2, THBS1, TIMP3] |
| GO: 0005146 | Amoebiasis | 740.0E-6 | 6.25 | 6.00 | [COL1A1, COL1A2, COL3A1, COL4A1, LAMB1, TGFB3] |
| GO: 0005144 | Malaria | 2.2E-3 | 8.16 | 4.00 | [LRP1, TGFB3, THBS1, THBS2] |
| GO: 0004350 | TGF-beta signaling pathway | 2.5E-3 | 5.95 | 5.00 | [GDF6, INHBA, NBL1, TGFB3, THBS1] |
| GO: 0004360 | Axon guidance | 3.6E-3 | 4.00 | 7.00 | [CAMK2A, CXCL12, NFATC2, SEMA3D, SEMA6B, SEMA7A, SLIT2] |
| GO: 0004392 | Hippo signaling pathway -multiple species | 4.2E-3 | 10.34 | 3.00 | [DCHS1, FRMD6, LATS2] |
| GO: 0004310 | Wnt signaling pathway | 5.6E-3 | 4.20 | 6.00 | [CAMK2A, FZD1, NFATC2, SERPINF1, SFRP2, SFRP4] |
| GO: 0005214 | Glioma | 5.9E-3 | 6.25 | 4.00 | [CAMK2A, IGF1, PDGFRA, PDGFRB] |
| GO: 0005218 | Melanoma | 7.7E-3 | 5.80 | 4.00 | [FGF7, IGF1, PDGFRA, PDGFRB] |
| GO: 0005414 | Dilated cardiomyopathy | 19.0E-3 | 4.44 | 4.00 | [IGF1, ITGA11, ITGA5, TGFB3] |
| GO: 0004115 | p53 signaling pathway | 43.0E-3 | 4.35 | 3.00 | [IGF1, SERPINE1, THBS1] |