. 2018 May 24;7(2):45. doi: 10.3390/antibiotics7020045

Table 1.

Compounds discovered by physicochemical screening of actinomycete strains (March 2018).

No.	Compound	Producing Microorganism	Source	Biological Activity	References
1	Bisoxazolomycin	Streptomyces subflavus subsp. irumaensis AM-3603	* KML Irumamycin producing strain, ** 36 years	Antibacterial	[32]
2	Iminimycin A & B	Streptomyces griseus OS-3601	* KML, Streptomycin producing strain, ** 43 years	Antibacterial	[33,34]
3	Nanaomycin F–H	“Streptomyces rosa subsp. Notoensis” OS-3966	* KML Nanaomycin producing strain, ** 36 years	Inhibitor of Epithelial-Mesenchymal Transition induced cells	[35,36]
4	Actinoallolide A–E	Actinoallomurus fulvus MK10-036	Roots of Capsicum frutescents in Thailand	Antitrypanosomal	[37]
4	Actinoallolide A–E	A. fulvus K09-0307	Roots of mondo grass in Saitama Pref., Japan	Antitrypanosomal	[37]
5	Hamuramicin A & B	Allostreptomyces sp. K12-0794	Roots of fern in Hamura city, Tokyo, Japan	Antibacterial	[38]
6	Spoxazomicin A–C	Streptosporangium oxazolinicum K07-0460^T	Roots of orchid in Iriomote Island, Japan	Antitrypanosomal	[39,40]
7	Trehangelin A–C	Polymorphospora rubra K07-0510	Roots of orchid in Iriomote Island, Japan	Anti-Lipid peroxidation	[41,42]
7	Trehangelin A–C	Polymorphospora rubra K07-0510	Roots of orchid in Iriomote Island, Japan	Enhanced production of collagen	[41,42]
8	Mangromicin A–I	Lechevalieria aerocolonigenes K10-0216	Sediment from mangrove forest in Iriomote Island, Japan	Antitrypanosomal	[43,44,45]
8	Mangromicin A–I	Lechevalieria aerocolonigenes K10-0216	Sediment from mangrove forest in Iriomote Island, Japan	Antioxidative	[43,44,45]
9	K10-0216 KA & KB	Lechevalieria aerocolonigenes K10-0216	Sediment from mangrove forest in Iriomote Island, Japan	Inhibitory effect on the lipid accumulation	[46]
10	Pyrizomicin A & B	Lechevalieria aerocolonigenes K10-0216	Sediment from mangrove forest in Iriomote Island, Japan	Antimicrobial	[47]
11	Mumiamicin	Mumia sp. YSP-2-79	Sea sediment, Namako Pond in Kagoshima Pref., Japan	Antibacterial	[48]
11	Mumiamicin	Mumia sp. YSP-2-79	Sea sediment, Namako Pond in Kagoshima Pref., Japan	Antioxidative	[48]
12	Sagamilactam	Actinomadura sp. K13-0306	Soil, Kanagawa Pref., Japan	Cytotoxicity	[49]
12	Sagamilactam	Actinomadura sp. K13-0306	Soil, Kanagawa Pref., Japan	Antitrypanosomal	[49]
13	Dipyrimicin A & B	Amycolatopsis sp. K16-0194	Soil, Okinawa Pref., Japan	Antibacterial	[50]

* KML: Kitasato Microbial Library, ** length of preservation by lyophilization; No. 1–3: Compounds from the KML; No. 4–13: Compounds from fresh isolates (No. 4–7; Roots of plants, No. 8–10; Sediment of mangrove forest, No. 11; Marine sediment, Nos. 12 & 13; Soil).