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Biogenesis of microRNA: The biogenesis of miRNAs. miRNA is transcribed in the nucleus as a pri-miRNA and then is micro-processed by Drosha, a class 2 ribonuclease III enzyme, and transported to the cytoplasm by exportin 5 (XPO5) where the hairpin structure is removed by Dicer and a single-stranded mature miRNA is produced, which binds to RISC and induces gene silencing.
