Table 1.

List of miRNAs in metastatic PC.

Function	mRNA	Target	Reference
Tumor growth	miR-125b	p53, Puma, and Bak1	54,55
	miR-155	ANX7	54,73
	miR-27a	MAP2K4	60
Neoplastic transformation intumor recruited stem cells	miR-125b	p53	53
	miR-130b	TP53INP1	53
	miR-155	p53	53
EMT and migration	miR-1	Src, TWIST1, Slug	79,85,86
	miR-29b	Snail	80
	miR-34b	AKT	78
	miR-145	ZEB2	80
	miR-146a	EGFR	84
	miR-200	Slug	79
	miR-205	CENPF, ZEB2 and PKCε	82,83
	miR-130b	MMP2	81
	miR-212	SOX4	75
CAFs (cancer-associated fibroblasts)and angiogenesis	miR-15 and miR-16	Bcl-2, Ccnd1, Ccne1, Bmi-1 andWnt family members	52
	miR-21	RECK	65,67
	miR-133b	EGFR	70
	miR-205	CENPF, ZEB2 and PKCε	82,83
	miR-409	RSU1, and PHC3	64,69
Extravasation and colonization of distant organs	miR-1	Src, TWIST1, Slug	79,85,86
	miR-96	AKT1S1	65
	miR-145	ZEB2	80
	miR-154*	STAG2	63
	miR-203	SRC, SUZ12, API5 , BIRC2, EREG, TRIAP1 and TGF-α	88
	miR-224	TRIB1	87
	miR-409-5p	STAG2, NPRL2, RSU1 and RBL2	64
Tumor suppressor	miR-9	E-cadherin and SOCS5	56
	miR-18	STK4	58
	miR-22	E-cadherin	55
	miR-146b		76
	miR-30a	SIX1	78
	miR-335	eNOS	77