Figure 7.

A quartz chip microfluidic device was designed for SERS at 785 nm excitation. At three separate inlets of the microfluidic device, AgNPs, KCl, and the cell lysate are injected and flow to combine together (left). Mineral oil is added to the initial mixture to act as a separation medium for the formation of droplets. SERS measurements (middle) of the droplets are acquired at a midpoint in the device. PCA of SERS spectra clearly shows separation and identification of the three leukemia cell lysates using variations in band intensity between the spectra (right). Figure adapted and reprinted from Ref. [114] by permission from Springer Customer Service Centre GmbH: Springer, Copyright Springer-Verlag GmbH Germany 2017 (2017).