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. 2018 May 22;7(2):44. doi: 10.3390/antibiotics7020044

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Natural products produced by actinomycetes detected and annotated by IMS. Fifteen known bioactive compounds were identified in different co-cultivation experiments. Only methylenomycin [239] exclusively had been detected using SIMS, whereas all molecules identified with Nano-DESI were also detectable by MALDI-TOF. Undecylprodigiosin [239,240] and actinorhodin [239,240] could be identified by all of the three methods. Prodiginine [240], coelichelin [240], different desferrioxamine derivatives [240], surfactin and plipastatin [241,242] could be assigned by NanoDESI and MALDI-TOF. Chalcomycin [243], daptomycin [243], actinomycin D [244], efomycin G [244], elaiochelin [244], linearmycin [243,245] and arylomycin [231] were only detected by MALDI-TOF.