Table 2.

Biosynthetic cluster specific methods and some successful examples of their enforcement.

Methods	Microorganism	Product	Effect	Ref.
Engineering Self-Resistance	S. peucetius	Doxorubicin, Daunorubicin	Enhance	[93]
	S. avermitilis	Avermectin,	Enhance	[94]
	S. coelicolor	Actinorhodin	Enhance	[95]
Regulatory Engineering
Delete repressor AbsA2~P	S. coelicolor	Actinorhodin, Undecylprodigiosin, Calcium-dependent antibiotic	Enhance	[96]
Overexpress AverR/StrR	S. avermitilis	Avermectin	Enhance	[97]
Overexpress AverR/StrR	S. griseous	Streptomycin	Enhance	[98]
Overexpress SamR0484	S. ambofaciens	Stambomicin A-D	Cryptic	[99]
Delete repressor cmmRII	S. griseus	Chromomycin	Enhance	[100]
Delete repressor AlpW	S. ambofaciens	Alpomycin	Enhance	[101]
Heterologous Expression	S. avermitilis	Streptomycin	Enhance	[102]
	S. coelicolor	Chloramphenicol	Enhance	[103]
	S. coelicolor	Congocidine	Enhance	[103]
	S. cyaneus	CECT 3335 laccase	Enhance	[27]
	S. lividans TK24	Mithramycin A	Enhance	[104]
	Streptomyces sp.	Neothioviridamide	Cryptic	[105]
	Several wild-type	Siamycin-I	Cryptic	[29]
Combinatorial Biosynthesis	S. albus J1074	Novel paulomycin	Cryptic	[31]
	See table 1 in ref.			[30]
Conditioning Morphology (PCD + MII)	S. albus	Apigenin, Luteolin	Enhance	[15]
	S. mobarensis	Microbial transglutaminase	Enhance	[14]