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Ca2+ binding by structured motifs of calmodulin and calreticulin. Calcium ions in green. (A) Calmodulin without calcium (well-structured), PDB_1CFC (B) Calcium-bound calmodulin, PDB_1UP5. The structure has changed, but remains well-ordered. (C) Calmodulin bound to a fragment of calcineurin PDB_2JZI. (D) Globular domain of calreticulin containing a single, high-affinity Ca2+ binding site, PDB_3POW.
