Table 3.
MICs (Minimal Inhibitory Concentrations) of α-770 and α-823 in comparison with salinomycin.
| Microorganism a | Code | MIC (µg/mL) | ||
|---|---|---|---|---|
| α-770 | α-823 | Salinomycin | ||
| Staphylococcus aureus (MSSA) | ATCC 6538P | 0.125 | 0.5 | 0.25 |
| S. aureus (MRSA) | L1400 | 0.125 | 2 | 0.5 |
| S. aureus (GISA) | L3797 | 0.125 | 1 | 0.125 |
| Streptococcus pyogenes | L49 | ≤0.03 | ≤0.03 | ≤0.03 |
| S. pneumoniae | L44 | ≤0.03 | 0.125 | 0.125 |
| S. haemolyticus | L1730 | 0.125 | 1 | 0.5 |
| S. epidermidis | ATCC 12228 | 0.125 | 1 | 0.5 |
| Enterococcus faecalis | L559 | ≤0.03 | 0.25 | ≤0.03 |
| E. faecium | L568 | 0.25 | 1 | 1 |
| Bacillus subtilis | ATCC 6633 | ≤0.03 | 0.125 | 0.125 |
| Micrococcus luteus | ATCC 10240 | 0.125 | 0.5 | 0.5 |
| Mycobacterium smegmatis | mc2 155 | 16 | 2 | 64 |
| Moraxella catarrhalis | L3292 | 2 | 8 | 16 |
| Clostridium difficile | L4013 | 0.5 | 0.125 | 0.25 |
| Candida albicans | L145 | >64 | >64 | >64 |
a abbreviations: MRSA, methicillin-resistant Staphylococcus aureus; MSSA, methicillin-sensitive Staphylococcus aureus; GISA, glycopeptide-intermediate Staphylococcus aureus.