Table 1.

Clinical diagnosis and laboratory tests

Clinical diagnosis*	Laboratory test
General parameters:Fever or hypothermia; HR above the normal value for age; tachypnea; altered mental status; significant edema or positive fluid balance; hyperglycemia in the absence of diabetes	Survival, body temperature, HR, blood lactate, GLU
Inflammatory parameters: Leukocytosis; leukopenia; plasma CRP level above the normal value; plasma PCT above the normal value	WBC, CRP, PCT, sTREM-1, CD163, HIF-1α, IL-6, IL-10, TNF-α, MIP-1α, MIP-1β, MIP-2
Hemodynamic parameters: Arterial hypotension or a decrease in SBP; mixed venous oxygen saturation of >70%; cardiac index of >3.5 L min−1 m−2	SBP
Organ dysfunction parameters: Arterial hypoxemia; acute oliguria; CREA increase; coagulation abnormalities; ileus (absent bowel sounds); thrombocytopenia; hyperbilirubinemia	Hypoxemia: blood lactateKidney: BUN, CREALiver: ALT AST ALB TP GLOBCoagulation: PLT, PT, APTT
Tissue perfusion parameters: Hyperlactatemia; decreased capillary refill or mottling	Blood lactate

*Some of the clinical diagnostic indicators listed in the table are interrelated with the indicators detected in this study; however, the table does not list all possible clinical features of sepsis.

HR, heart rate; GLU, glucose; CRP, C-reactive protein; PCT, procalcitonin; WBC, white blood cell; sTREM, soluble triggering receptor expressed on myeloid cells; HIF, hypoxia-inducible factor; IL, interleukin; TNF, tumor necrosis factor; MIP, macrophage inflammatory protein; SBP, systolic blood pressure; BUN, blood urea nitrogen; CREA, creatinine; ALT, alanine transaminase; AST, aspartate transaminase; ALB, albumin; TP, total protein; GLOB, globulin; PCT, procalcitonin; PT, prothrombin time; APTT, activated partial thromboplastin time.