Table 2.

Univariate and multivariate analysis of factors associated with early mortality

	Univariate analysis		Multivariate analysis
	OR (95% CI)	P value	OR (95% CI)	P value
Age of ≥75 years	7.364 (2.297–23.605)	0.001	8.583 (1.932–38.128)	0.005
IgA	1.788 (0.614–5.205)	0.287
DS III	2.037 (0.245–16.97)	0.511
ISS III	4.667 (1.396–15.596)	0.012	5.506 (1.077–28.157)	0.041
WHO performance status ≥3	0.812 (0.279–2.366)	0.703
Charlson comorbidity index ≥5	3.583 (1.148–11.179)	0.028	0.987 (0.19–5.112)	0.987
Hemoglobin <10 g/L	4.714 (0.589–37.741)	0.144
Lactate dehydrogenase >normal	9.706 (2.98–31.617)	0.000	10.234 (2.596–40.341)	0.001
Creatinine >177 µmol/L	3.444 (1.144–10.368)	0.028	1.692 (0.327–8.751)	0.531
Calcium >2.75 mmol/L	0.405 (0.049–3.333)	0.401
Bortezomib-based regimen from diagnosis to RRMM, range	3.273 (0.983–10.901)	0.053

ISS: International Staging System; DSS: Durie–Salmon staging system; WHO: World Health Organization; OR: odds ratio; CI: confidence interval.