Table 1. Agreement and comparative accuracy of MYCOTB plate with LJ and MB7H10 for first-line drug susceptibility testing.
| Reference Method | MB7H10 | MYCOTB plate | LJ/ MB7H10 |
LJ/ MYCOTB plate |
MYCOTB plate | Reference method | MYCOTB plate | MYCOTB plate | MB7H10 /MYCOTB plate |
||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| LJ DST (μg/mL) | LJ DST | R | S | R | S | Kappa | Kappa | Sensitivity/ Specificity (95%CI) | MB7H10 (μg/mL) | R | S | Sensitivity/ Specificity (95%CI) | Kappa |
| STR (4.0) | R | 13 | 26 | 14 | 25 | 0.275 | 0.300 | 87.5 (61.6–98.4) | STR (10) | 15 | 0 | 93.8 (69.7–99.8) | 0.959 |
| S | 2 | 35 | 2 | 35 | 58.3 (44.8–70.9) | 1 | 60 | 100 | |||||
| INH (0.2) | R | 15 | 12 | 22 | 15 | 0.498 | 0.496 | 75.9 (65.1–95.6) | INH (1.0) | 25 | 7 | 96.2 (80.3–99.9) | 0.778 |
| S | 7 | 32 | 4 | 35 | 70.0 (55.3–82.1) | 1 | 43 | 86.0 (73.2–94.1) | |||||
| RIF (40) | R | 22 | 4 | 19 | 7 | 0.687 | 0.591 | 73.1 (52.2–88.4) | RIF (1.0) | 26 | 3 | 100 | 0.915 |
| S | 7 | 43 | 7 | 43 | 86.0(73.2–94.1) | 0 | 47 | 94.0 (83.4–98.7) | |||||
| EMB (2.0) | R | 1 | 17 | 1 | 17 | 0.082 | 0.082 | 100 | EMB (10) | 1 | 0 | 100 | 1.00 |
| S | 0 | 58 | 0 | 58 | 77.3(66.2–86.2) | 0 | 75 | 100 | |||||
R = resistant, S = Susceptible, CI = confidence interval, LJ = Lowenstein Jensen, MB = Middlebrook, MYCOTB = sensititre MYCOTB plate, STR = streptomycin, INH = isoniazid, RIF = rifampicin, EMB = ethambutol