Table 2. Diagnostic accuracies of APRI and FIB-4 for predicting liver fibrosis (all patients, N = 1716).

Index	AUROCcutoff	cutoff	sensitivitycutoff	specificitycutoff	PPVcutoff	NPVcutoff	Sensitivity + Specificity-1
To predict fibrosis ≥2
APRI	0.68 (0.66–0.70)	1.4	72.4%	63.2%	68.9%	67.1%	35.6%
FIB-4	0.70 (0.68–0.72)	2.9	62.7%	78.0%	76.2%	65.0%	40.6%
To predict fibrosis ≥3
APRI	0.68 (0.66–0.70)	1.6	67.1%	68.8%	62.3%	62.3%	36.6%
FIB-4	0.73 (0.71–0.75)	2.9	69.1%	76.1%	68.9%	76.3%	45.2%
To predict fibrosis = 4
APRI	0.70 (0.68–0.73)	2.2	64.9%	75.4%	47.3%	86.3%	40.3%
FIB-4	0.73 (0.70–0.75)	3.1	72.0%	73.4%	47.9%	88.5%	46.6%

APRI, aspartate aminotransferase (AST)- to-platelet ratio index; FIB-4, fibrosis index based on the four factors; AUROC, area under receiver operating characteristic