Table 3. Diagnostic accuracies of APRI and FIB-4 for predicting liver fibrosis (AST≤37 IU/L, N = 132).
| Index | AUROCcutoff | Bootstrap AUROCcutoff | cutoff | sensitivitycutoff | specificitycutoff | PPVcutoff | NPVcutoff | Sensitivity + Specificity-1 |
|---|---|---|---|---|---|---|---|---|
| To predict fibrosis ≥2 | ||||||||
| APRI | 0.65 (0.56–0.75) | 0.65 (0.56–0.75) | 0.5 | 46.9% | 84.0% | 48.4% | 83.2% | 33.9% |
| FIB-4 | 0.67 (0.58–0.76) | 0.67(0.57–0.77) | 1.6 | 46.9% | 87.0% | 53.6% | 83.7% | 43.4% |
| To predict fibrosis ≥3 | ||||||||
| APRI | 0.73 (0.62–0.83) | 0.73 (0.62–0.84) | 0.6 | 60.9% | 84.4% | 45.2% | 91.1% | 45.3% |
| FIB-4 | 0.77 (0.67–0.86) | 0.767 (0.67–0.86) | 1.4 | 78.3% | 75.2% | 40.0% | 94.3% | 53.5% |
| To predict fibrosis = 4 | ||||||||
| APRI | 0.81 (0.65–0.98) | 0.81 (0.64–1.0) | .6 | 83.3% | 79.4% | 16.1% | 99.0% | 62.7% |
| FIB-4 | 0.85 (0.81–0.89) | 0.85 (0.81–0.89) | 1.4 | 100.0% | 69.1% | 13.3% | 100.0% | 69.1% |
APRI, aspartate aminotransferase (AST)- to-platelet ratio index; FIB-4, fibrosis index based on the four factors; AUROC, area under receiver operating characteristic