Table 4. Diagnostic accuracies of APRI and FIB-4 for predicting liver fibrosis (37<AST≤74, N = 501).
| Index | AUROCcutoff | Bootstrap AUROCcutoff | cutoff | sensitivitycutoff | specificitycutoff | PPVcutoff | NPVcutoff | Sensitivity + Specificity-1 |
|---|---|---|---|---|---|---|---|---|
| To predict fibrosis ≥2 | ||||||||
| APRI | 0.65 (0.60–0.69) | 0.65 (0.60–0.69) | 1.1 | 50.8% | 78.4% | 60.0% | 71.4% | 29.2% |
| FIB-4 | 0.65 (0.61–0.69) | 0.65 (0.60–0.69) | 2.2 | 53.3% | 76.1% | 58.8% | 71.9% | 29.5% |
| To predict fibrosis ≥3 | ||||||||
| APRI | 0.69 (0.64–0.73) | 0.69 (0.64–0.73) | 1.0 | 59.2% | 78.0% | 52.7% | 82.1% | 37.3% |
| FIB-4 | 0.70(0.65–0.74) | 0.70(0.65–0.74) | 2.2 | 63.3% | 76.3% | 52.5% | 83.3% | 39.5% |
| To predict fibrosis = 4 | ||||||||
| APRI | 0.71 (0.66–0.77) | 0.71 (0.66–0.77) | 1.1 | 68.3% | 74.0% | 33.9% | 92.3% | 42.3% |
| FIB-4 | 0.72 (0.67–0.77) | 0.719 (0.67–0.77) | 2.2 | 72.0% | 71.8% | 33.3% | 92.9% | 43.8% |
APRI, aspartate aminotransferase (AST)- to-platelet ratio index; FIB-4, fibrosis index based on the four factors; AUROC, area under receiver operating characteristic