Table 5. Diagnostic accuracies of APRI and FIB-4 for predicting liver fibrosis (74<AST≤148 IU/L, N = 737).
| Index | AUROCcutoff | Bootstrap AUROCcutoff | cutoff | sensitivitycutoff | specificitycutoff | PPVcutoff | NPVcutoff | Sensitivity + Specificity-1 |
|---|---|---|---|---|---|---|---|---|
| To predict fibrosis ≥2 | ||||||||
| APRI | 0.66 (0.63–0.69) | 0.66 (0.63–0.69) | 1.9 | 51.9% | 79.8% | 80.6% | 50.7% | 33.3% |
| FIB-4 | 0.69 (0.65–0.72) | 0.69 (0.65–0.72) | 3.0 | 62.2% | 74.8% | 79.9% | 55.1% | 37.0% |
| To predict fibrosis ≥3 | ||||||||
| APRI | 0.69 (0.66–0.72) | 0.69 (0.66–0.72) | 2.2 | 55.4% | 82.5% | 76.8% | 63.9% | 37.9% |
| FIB-4 | 0.71 (0.68–0.74) | 0.71 (0.69–0.76) | 3.2 | 64.7% | 76.9% | 74.6% | 67.6% | 41.7% |
| To predict fibrosis = 4 | ||||||||
| APRI | 0.72 (0.68–0.76) | 0.72 (0.69–0.76) | 2.2 | 67.4% | 76.7% | 56.3% | 84.1% | 44.1% |
| FIB-4 | 0.73 (0.69–0.76) | 0.73 (0.69–0.76) | 3.4 | 70.0% | 74.9% | 55.4% | 84.9% | 45.7% |
APRI, aspartate aminotransferase (AST)- to-platelet ratio index; FIB-4, fibrosis index based on the four factors; AUROC, area under receiver operating characteristic