Table 6. Diagnostic accuracies of APRI and FIB-4 for predicting liver fibrosis (AST>148 IU/L, N = 346).
| Index | AUROCcutoff | Bootstrap AUROCcutoff | cutoff | sensitivitycutoff | specificitycutoff | PPVcutoff | NPVcutoff | Sensitivity + Specificity-1 |
|---|---|---|---|---|---|---|---|---|
| To predict fibrosis ≥2 | ||||||||
| APRI | 0.68 (0.62–0.73) | 0.676 (0.62–0.73) | 3.4 | 65.0% | 70.0% | 80.3% | 51.5% | 36.5% |
| FIB-4 | 0.68 (0.63–0.73) | 0.68 (0.63–0.73) | 3.4 | 79.7% | 56.7% | 77.6% | 59.7% | 38.6% |
| To predict fibrosis ≥3 | ||||||||
| APRI | 0.68 (0.63–0.73) | 0.68 (0.63–0.73) | 3.4 | 68.2% | 67.6% | 73.8% | 61.4% | 38.3% |
| FIB-4 | 0.70 (0.65–0.74) | 0.70 (0.65–0.74) | 5.2 | 58.6% | 80.4% | 80.0% | 59.2% | 39.2% |
| To predict fibrosis = 4 | ||||||||
| APRI | 0.68 (0.64–0.73) | 0.68 (0.64–0.73) | 3.4 | 76.9% | 60.0% | 50.8% | 82.8% | 40.4% |
| FIB-4 | 0.70 (0.65–0.75) | 0.70 (0.65–0.75) | 5.5 | 61.2% | 79.1% | 61.2% | 79.1% | 43.5% |
APRI, aspartate aminotransferase (AST)- to-platelet ratio index; FIB-4, fibrosis index based on the four factors; AUROC, area under receiver operating characteristic