Table 7. Diagnostic accuracies of APRI and FIB-4 for predicting liver fibrosis (Minimal-mild necroinflammation score 1–8, N = 1171).

Index	AUROCcutoff	Bootstrap AUROCcutoff	cutoff	sensitivitycutoff	specificitycutoff	PPVcutoff	NPVcutoff	Sensitivity + Specificity-1
To predict fibrosis ≥2
APRI	0.63 (0.61–0.66)	0.63 (0.61–0.66)	1.0	43.6%	83.1%	66.9%	65.3%	27.9%
FIB-4	0.65(0.63–0.67)	0.65 (0.63–0.67)	1.4	91.3%	39.0%	53.9%	85.1%	34.0%
To predict fibrosis ≥3
APRI	0.67 (0.64–0.70)	0.67 (0.64–0.70)	1.4	69.7%	64.3%	51.5%	79.6%	34.0%
FIB-4	0.71(0.69–0.74)	0.71 (0.69–0.74)	2.8	63.7%	79.2%	62.5%	80.0%	42.9%
To predict fibrosis = 4
APRI	0.69 (0.66–0.72)	0.69 (0.66–0.72)	1.4	78.2%	60.5%	34.7%	91.2%	38.7%
FIB-4	0.73(0.70–0.76)	0.73 (0.70–0.76)	2.8	72.6%	73.9%	2.8%	90.9%	48.0%

APRI, aspartate aminotransferase (AST)- to-platelet ratio index; FIB-4, fibrosis index based on the four factors; AUROC, area under receiver operating characteristic