. 2018 Jun 28;13(6):e0199760. doi: 10.1371/journal.pone.0199760

Table 8. Diagnostic accuracies of APRI and FIB-4 for predicting liver fibrosis (Moderate to severe necroinflammation score 9–18, N = 540).

Index	AUROC_cutoff	Bootstrap AUROC_cutoff	cutoff	sensitivity_cutoff	specificity_cutoff	PPV_cutoff	NPV_cutoff	Sensitivity + Specificity-1
To predict fibrosis ≥2
APRI	0.65 (0.61–0.70)	0.65(0.61–0.70)	2.2	61.5%	69.3%	83.9%	40.9%	30.9%
FIB-4	0.68 (0.64–0.72)	0.68 (0.64–0.73)	3.0	67.4%	68.8%	84.8%	44.8%	36.1%
To predict fibrosis ≥3
APRI	0.65(0.61–0.69)	0.68 (0.64–0.72)	1.4	84.3%	45.0%	70.8%	64.4%	36.5%
FIB-4	0.71 (0.67–0.75)	0.70 (0.66–0.74)	2.9	76.1%	65.1%	77.5%	63.3%	41.2%
To predict fibrosis = 4
APRI	0.68 (0.64–0.72)	0.68 (0.64–0.72)	2.2	76.1%	59.4%	50.0%	82.3%	35.4%
FIB-4	0.70(0.66–0.74)	0.70 (0.66–0.74)	5.0	54.3%	84.9%	65.8%	77.7%	39.7%

APRI, aspartate aminotransferase (AST)- to-platelet ratio index; FIB-4, fibrosis index based on the four factors; AUROC, area under receiver operating characteristic