Table 2. IC50 value and sensitivity index in stable CCA cell lines to gemcitabine.
Conditions | IC50 value of gemcitabine (μM) | |||||
---|---|---|---|---|---|---|
Normoxia | SI | P-value | Hypoxia | SI | P-value | |
KKU-213-pMSCV | 0.10±0.02 | 0.42±0.21 | ||||
KKU-213-pMSCV-miR210 | 0.09±0.01 | 1.12 | 0.257 | 3.58±1.23 | 0.12 | 0.013* |
KKU-100-control vector | 0.46±0.05 | 0.81±0.07 | ||||
KKU-100-miR210 sponge | 0.07±0.01 | 7.03 | <0.001* | 0.09±0.01 | 9.26 | 0.003* |
SI, sensitivity index.
*P-value less than 0.05 was considered statistically significant.