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Generation of reactive species by reduction of NBD compounds. Lipophilic compounds generate reactive oxygen species (ROS) and concomitant reactive electrophilic species (RES), which independently react with a variety of proteins. The Cu/Zn superoxide dismutase 1 (SOD1) dimers trigger new rounds of O2 redox cycling leading to the production of excess H2O2 in cancer cells. The reduction of the nitro group is described in Reference [48].
