Table 1.

Summary of the types of cells to which Candida glabrata can adhere in vitro and in vivo, the receptors in host cells, microorganisms, or substrates involved in the interaction, and the ligand on C. glabrata recognized by the receptor.

Interaction with		Receptor in the Host or Microorganism b	Ligand on C. glabrata d	Reference
Type of Cells	Specific Cell Line a
Epithelial cells	HEp2 (human), CHO-Lec2 (hamster)	ND c	Epa1	[11]
	Cardiac endothelium (guinea pig)	ND	ND	[15]
	Caco-2 (human)	ND	Epa1	[29]
	Lec2 (hamster)	ND	Epa6, Epa7	[33]
	OKF6/TERT-2 (human)	ND	β-glucan	[76]
	UVECS (human)	ND	Pwp7, Aed1	[14]
	OKF6/TERT-2 (human)	CDw17	ND	[77]
Immune cells	Natural Killers (NK)	Nkp46 (human) NCR1 (murine)	Epa1, Epa6, Epa7	[18]
	Macrophages (human/murine)	Dectin1, Dectin2	β-glucan	[73,74,75]
		ND	Epa1	[17]
	Dendritic Cells (murine)	ND	Epa1/ND	[16,17]
	Neutrophils (murine)	Dectin2	β-glucan	[73]
Platelets (murine)		ND	ND	[78]
Candida spp.	C. albicans (hyphae)	Hwp1, Als3, Als1	Epa8, Epa19, Awp2, Awp7, CAGL0F00181	[79]
	C. krusei	ND	ND	[80,81]
Others	Fibronectin		Epa6	[82]
	Osteoblast (human)	ND	ND	[83]
	S. marscesens, P. aeruginosa, A. fumigatus	NI e	NI	[84,85,86]

^a Name of the cell lines or types of immune cells used to determine adherence. Abbreviations mean: HEp2 = Human Epidermoid cancer cells. CHO = Chinese Hamster Ovary. Lec2 = CHO derived mutants in CMP-syalic acid translocation. Caco-2 = adeno Carcinoma of the colon. OKF6/TERT-2 = human Oral Keratinocytes expressing hTERT subunit. UVEC = Umbilical Vein Endothelial Cells. The origin of the cell type (human or murine) is indicated in parenthesis. ^b Receptor identified on the surface of the cell to which C. glabrata adheres. ^c ND means not determined. ^d Ligand identified on C. glabrata that is recognized by the receptor. ^e NI means not investigated.