Table 2.
Characteristics of the human organic anion transporters of the SLC22A family.
| Major Clade | Subclade | Gene | Protein | Tissue Distribution | Endogenous Substrates | Xenobiotic Substrates/Inhibitors |
|---|---|---|---|---|---|---|
| OAT | Oat | SLC22A6 | OAT1 | Kidney, brain | cGMP, C5- and C6-mono and dicarboxylates, prostaglandins, urate | Acyclovir, adefovir, captopril, cidofovir, cimetidine, furosemide, ganciclovir, methotrexate, olmesartan, tenofovir, ranitidine |
| OAT | Oat | SLC22A7 | OAT2 | Liver, kidney | Conjugated steroid hormones, cGMP, nucleobases, nucleosides, nucleotides, prostaglandins | Acyclovir, cimetidine, diclofenac, entecavir, erythromycin, ganciclovir, irinotecan, methotrexate, penciclovir, ranitidine, tetracycline, 5-FU |
| OAT | Oat | SLC22A8 | OAT3 | Kidney, retina, brain | Acidic neurotransmitter metabolites, bile acids, C5-dicarboxylates, cAMP, cGMP, conjugated steroid hormones, prostaglandins, urate | Cimetidine, benzylpenicillin, bumetanide, cephalosporins, ciprofloxacin, furosemide, methotrexate, NSAIDs, pravastatin, probenecid, rosuvastatin, zidovudine |
| OAT | Oat | SLC22A9 | OAT7 | Liver | Conjugated steroid hormones, monocarboxylates, short chain fatty acids | Pravastatin |
| OAT | Oat | SLC22A10 | OAT5 | Liver | Unknown | |
| OAT | Oat | SLC22A11 | OAT4 | Kidney, placenta, adrenal gland | Bile acids, C5-dicarboxylates, conjugated steroid hormones prostaglandins, urate | Bumetanide, hydrochlorothiazide, ketoprofen, methotrexate, salicylate, tetracycline, torsemide, zidovudine |
| OAT | Oat | SLC22A12 | URAT1 | Kidney | Urate | |
| OAT | Oat | SLC22A20 | OAT6 | Nasal epithelial cells | Conjugated steroid hormones, C5-dicarboxylates, short chain fatty acids | Sorafenib |
| OAT | Oat | SLC22A24 | S22AO | Kidney | Unknown | |
| OAT | Oat | SLC22A25 | UST6 | Liver | Unknown | |
| OAT | Oat-like | SLC22A13 | OAT10 | Kidney, brain, colon | C4-dicarboxylates, glutathione, nicotinate, urate | |
| OAT | Oat-like | SLC22A14 | OCTL2 | Testis, kidney | Unknown |