Table 2.

Functions of Endocannabinoids and Exocannabinoids in Cirrhosis.

AEA	Antifibrogenic; inhibits proliferation of HSC and induces necrotic death [30] Induces mesenteric vasodilation and hypotension via CB1 induction (in rodent studies) [18,19] Contributes to cirrhotic cardiomyopathy (in rodent studies) [24] Induces hepatocyte proliferation (in animal studies) [19]
2-AG	Fibrogenic mediator (in rodent studies) [18] Growth inhibitory and cytotoxic effects (in rodent studies) [18] In higher doses, induces apoptosis of HSCs, (antifibrogenic) (in rodent studies) [18] Improves hepatic encephalopathy (in rodent studies) [24,30]
THC	Suppresses proliferation of hepatic myofibroblasts and stellate cells (in rodent studies) [18] Induces apoptosis (in rodent studies) [18]
Cannabidiol	Improves cognitive, motor function, and neuroinflammation in hepatic encephalopathy (in human studies) [19]