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. 2018 Jun 18;11(6):e007451. doi: 10.1161/CIRCIMAGING.117.007451

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© 2018 The Authors.

Circulation: Cardiovascular Imaging is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 1. — Annualized changes in aortic valve obstruction, left ventricular hypertrophy, and diffuse fibrosis in the natural history and aortic valve replacement (AVR) groups. Annualized progression in peak aortic-jet velocity (A), left ventricular mass (B), and diffuse fibrosis (indexed extracellular volume [iECV], C) increased in a stepwise fashion with severity of aortic stenosis. The slowest progression for each parameter was observed in patients with mild aortic stenosis and the fastest progression in those with severe stenosis. Extracellular volume fraction (ECV%) did not change (D), suggesting balanced progression in cellular hypertrophy and interstitial fibrosis. After AVR, there was significant regression in valve obstruction (A), left ventricular mass index (LVMi; B), and iECV (diffuse fibrosis, C). ECV% increased (D) suggesting more rapid regression in cellular hypertrophy than interstitial diffuse fibrosis (all P<0.005). *Significant (P<0.005) annualized change comparing pre- and post-AVR values for each measure.