Table 1.
Generalized linear models for severity score models by organ system including pre-transplant risk factors.
| Generalized linear models | n (%) | Mean(IQR) | Coefficient | p value |
|---|---|---|---|---|
| Demographics/Environment | ||||
|
| ||||
| Age < 50.90 (1st quartile) | 87 | (28.2) | −0.531 | .12 |
| Age > 61.67 (3rd quartile) | 97 | (28.1) | 0.083 | .77 |
| Gender male | 241 | (70.0) | 0.301 | .30 |
| Race Caucasian | 283 | (82.2) | 0.388 | .28 |
| Smoking status at time of transplant | 48 | (13.9) | 0.138 | .69 |
| Waiting list time in days | 320.5 | (27–410.2) | <−0.0001 | .72 |
|
| ||||
| Primary disease reason for transplantation | ||||
|
| ||||
| Hepatocellular carcinoma and Cirrhosis | 55 | (15.9) | 0.375 | .30 |
| Alcoholic cirrhosis with hepatitis C | 30 | (8.7) | 0.757 | .07 |
| Cirrhosis: type C | 58 | (16.8) | 0.485 | .16 |
| Hepatocellular carcinoma | 8 | (2.3) | 0.939 | .21 |
| Cirrhosis: type B HBSAG+ | 14 | (4.0) | 0.862 | .14 |
|
| ||||
| Blood | ||||
|
| ||||
| Low hemoglobin | 138 | (40.1) | 0.157 | .55 |
| High lipids | 64 | (18.6) | −0.352 | .31 |
| Infection: non-viral | 56 | (16.2) | 0.273 | .41 |
| Low platelet | 70 | (20.3) | −0.453 | .18 |
|
| ||||
| Circulatory | ||||
|
| ||||
| Arrhythmia | 42 | (12.2) | −0.420 | .33 |
| Peripheral vascular disease | 6 | (1.7) | 1.788 | .06 |
| Coronary artery disease (CAD) | 22 | (6.3) | 1.458 | .004** |
| Varicose vein requiring surgery | 5 | (1.4) | 0.802 | .43 |
| Hypotensive crisis | 17 | (4.9) | −1.170 | .16 |
| Angina | 6 | (1.7) | −2.046 | .12 |
|
| ||||
| Endocrine | ||||
|
| ||||
| Failure to thrive or malnutrition requiring treatment | 34 | (9.8) | 0.562 | .15 |
| Adrenal insufficiency | 5 | (1.4) | 2.735 | .02* |
| Electrolyte imbalance requiring treatment | 5 | (1.4) | −1.324 | .37 |
|
| ||||
| Gastrointestinal & pancreas: native | ||||
|
| ||||
| Portal hypertensive gastropathy | 96 | (27.9) | 0.430 | .11 |
| Gastrointestinal benign mass or cyst not infected | 53 | (15.4) | 0.263 | .44 |
| Pancreas benign mass or cyst not infected | 9 | (2.6) | 0.367 | .61 |
| Pancreatitis: acute | 11 | (3.1) | −0.337 | .67 |
|
| ||||
| Kidney & ureter: native | ||||
|
| ||||
| Pre-transplant hemodialysis | 61 | (17.7) | 0.397 | .21 |
| Dysfunction with no dialysis | 81 | (23.5) | −0.210 | .49 |
| Bleed | 7 | (2.0) | 0.889 | .25 |
| Benign mass or cyst not infected | 16 | (4.6) | 0.719 | .18 |
|
| ||||
| Liver & biliary | ||||
|
| ||||
| Ascites | 138 | (40.1) | −0.267 | .31 |
| Biliary stones and/or calculi | 50 | (14.5) | −0.320 | .40 |
| Benign mass or cyst not infected | 14 | (4.0) | 0.647 | .26 |
| Cholangitis | 15 | (4.3) | −0.699 | .36 |
| Bile leak | 4 | (1.1) | 1.184 | .24 |
|
| ||||
| Respiratory | ||||
|
| ||||
| Acute respiratory distress syndrome (ARDS) | 52 | (15.1) | −0.051 | .88 |
| Asthma | 36 | (10.4) | 0.449 | .25 |
| Chronic obstructive pulmonary disease (COPD) | 26 | (7.5) | −0.398 | .45 |
|
| ||||
| Neurologic | ||||
|
| ||||
| Encephalopathy: hepatic | 245 | (71.2) | 0.462 | .12 |
| Sleep apnea | 28 | (8.1) | 0.481 | .26 |
| Seizures and/or epilepsy | 16 | (4.6) | 0.424 | .44 |
|
| ||||
| Mental illness | ||||
|
| ||||
| Alcohol abuse | 163 | (47.3) | 0.123 | .67 |
| Iv drug abuse | 84 | (24.4) | 0.220 | .50 |
| Depression requiring treatment | 105 | (30.5) | 0.205 | .44 |
| Bipolar disorder | 7 | (2.0) | −0.787 | .47 |
|
| ||||
| Musculoskeletal | ||||
|
| ||||
| Pain of unknown etiology | 23 | (6.6) | 0.886 | .05 |
| Carpal tunnel syndrome | 11 | (3.1) | −1.479 | .17 |
| Fibromyalgia | 6 | (1.7) | 1.452 | .09 |
|
| ||||
| Extremities (ears, nose, eyes, skin) | ||||
|
| ||||
| Hearing loss | 10 | (2.9) | −1.191 | .26 |
| Diabetic Retinopathy | 5 | (1.4) | 0.832 | .36 |
| Skin or subcutaneous infection: non-viral | 41 | (11.9) | 0.649 | .07 |
Note: Significant levels:
**
p value < 0.01,
*
p value < 0.05.