Figure 5.

Cisterna Magna Delivery of scAAV9_hSOD1si at P40 Improves Gait Parameters in SOD1^G93A Mice

(A–D) Analysis of individual gait parameters over time in SOD1^G93A transgenic mice injected with scAAV9_hSOD1si (n = 5) or scAAV9_hSOD1ssi (n = 5) in the cisterna magna at post-natal day 40 (P40). Selected gait parameters were analyzed using a two-way ANOVA with Sidak’s post hoc test. Forepaw stride length in millimeters (A), forepaw pixel intensity (B), hind paw stride length in millimeters (C), and hind paw swing speed in meters per second (D) for SOD1^G93A mice treated with scAAV9_hSOD1si or scAAV9_hSOD1ssi are shown. Data are presented as mean ± SEM. Differences were detectable at day 91. *p < 0.05 and **p < 0.01.