Figure 4.

The Stability of Engineered Bacteriophage at Different Acid pH and Enzymatic Fluids

(A) The effect of low pH on the survival of RGD-surface-modified bacteriophage. (B) LB-agar plates showing the colony formation of RGD-bacteriophage at different acid pH are shown. One representative plate of each bacteriophage is shown. (C) Stability of RGD-surface-modified bacteriophage under simulated gastric or intestinal conditions. Each measurement was performed in triplicate, and each experiment was repeated at least three times. The results are presented in mean infectivity (% of control) ± SEM. Significant difference: n.s., not significant, ***p < 0.001