Table 2.

Relationship between Circulating Levels of miRNAs and T2DM-Related Parameters

		hsa-miR103	hsa-miR28-3p	hsa-mir-126	hsa-miR150	hsa-miR30a-5p	hsa-miR9	hsa-miR375	hsa-miR223	hsa-miR29a
HbA1c (%)	r2	−0.112	−0.122	−0.017	0.070	0.056	−0.049	−0.125	−0.091	−0.060
	p	0.014*	0.008*	0.369	0.085	0.134	0.168	0.007*	0.037*	0.121
Glucosa (mg/dL)	r2	−0.129	−0.112	−0.099	0.107	0.109	−0.082	0.000	−0.039	0.019
	p	0.006*	0.014*	0.026*	0.018*	0.016*	0.054	0.497	0.220	0.354
Insulina (mU/L)	r2	0.011	−0.034	−0.041	0.027	0.031	−0.008	−0.003	0.030	0.006
	p	0.413	0.250	0.209	0.300	0.274	0.436	0.478	0.276	0.455
HOMA-IR	r2	0.016	−0.026	−0.013	0.010	0.001	0.059	0.027	−0.006	−0.040
	p	0.380	0.306	0.396	0.424	0.490	0.123	0.301	0.452	0.217
MISI	r2	−0.080	0.025	0.037	−0.012	0.046	−0.069	−0.015	0.048	−0.023
	p	0.059	0.313	0.236	0.409	0.182	0.089	0.385	0.172	0.323
IGI	r2	0.053	−0.016	−0.015	0.102	−0.021	0.080	−0.031	−0.013	0.030
	p	0.148	0.377	0.382	0.022*	0.340	0.060	0.269	0.398	0.280
ISI	r2	0.029	0.077	0.102	−0.041	0.000	−0.015	0.008	0.078	0.003
	p	0.283	0.065	0.023*	0.213	0.499	0.444	0.441	0.062	0.478
DI	r2	0.096	0.076	0.070	0.047	−0.045	0.054	−0.012	0.048	0.062
	p	0.030*	0.068	0.083	0.177	0.189	0.148	0.409	0.174	0.113
HIRI	r2	0.016	−0.033	−0.024	0.021	0.004	0.063	0.024	−0.010	−0.042
	p	0.376	0.228	0.316	0.340	0.467	0.328	0.319	0.422	0.208

HbA1c, glycosylated hemoglobin; GLU, glucose; HOMA-B, homeostasis model assessment-beta cell function; HOMA-IR, homeostasis model assessment-insulin resistance; MIRI, muscle insulin resistance index; IGI, insulinogenic index; ISI, insulin sensitivity index; DI, disposition index; HIRI, hepatic insulin resistance index. Relationship was evaluated through a linear regression analysis adjusted by age, gender, body mass index (BMI), triglycerides (TG), and high-density lipoproteins (c-HDL), using SPSS (now PASW Statistic for Windows, version 21.0) (IBM, Chicago, IL, USA). *p < 0.05 in the linear regression analysis.